Structural Basis for Allosteric Coupling at the Membrane-Protein Interface in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC)

Ligand binding at the extracellular domain of pentameric ligand-gated ion channels initiates a relay of conformational changes that culminates at the gate within the transmembrane domain. The interface between the two domains is a key structural entity that governs gating. Molecular events in signal...

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Main Authors: Velisetty, Phanindra, Chalamalasetti, Sreevatsa V., Chakrapani, Sudha
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Molecular Biophysics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908432/
https://ncbi.nlm.nih.gov/pubmed/24338475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523050
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