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Compound-specific Na(+) channel pore conformational changes induced by local anaesthetics
Upon prolonged depolarizations, voltage-dependent Na(+) channels open and subsequently inactivate, occupying fast and slow inactivated conformational states. Like C-type inactivation in K(+) channels, slow inactivation is thought to be accompanied by rearrangement of the channel pore. Cysteine-label...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456037/ https://ncbi.nlm.nih.gov/pubmed/15677685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.081646 |
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