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Novel Molecular Determinants in the Pore Region of Sodium Channels Regulate Local Anesthetic Binding
The pore of the Na(+) channel is lined by asymmetric loops formed by the linkers between the fifth and sixth transmembrane segments (S5-S6). We investigated the role of the N-terminal portion (SS1) of the S5-S6 linkers in channel gating and local anesthetic (LA) block using site-directed cysteine mu...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2769053/ https://ncbi.nlm.nih.gov/pubmed/19620257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.055863 |
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