Novel Molecular Determinants in the Pore Region of Sodium Channels Regulate Local Anesthetic Binding

The pore of the Na(+) channel is lined by asymmetric loops formed by the linkers between the fifth and sixth transmembrane segments (S5-S6). We investigated the role of the N-terminal portion (SS1) of the S5-S6 linkers in channel gating and local anesthetic (LA) block using site-directed cysteine mu...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Yamagishi, Toshio, Xiong, Wei, Kondratiev, Andre, Vélez, Patricio, Méndez-Fitzwilliam, Ailsa, Balser, Jeffrey R., Marbán, Eduardo, Tomaselli, Gordon F.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2009
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769053/
https://ncbi.nlm.nih.gov/pubmed/19620257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.055863
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky