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Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form

It is hypothesized that infectious prions are generated as the cellular form of the prion protein (PrP(C)) undergoes pronounced conformational change under the direction of an infectious PrP(Sc) template. Conversion to the infectious conformer is particularly associated with major structural rearran...

詳細記述

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書誌詳細
主要な著者: Leclerc, Estelle, Peretz, David, Ball, Haydn, Sakurai, Hiroshi, Legname, Giuseppe, Serban, Ana, Prusiner, Stanley B., Burton, Dennis R., Williamson, R.Anthony
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC145482/
https://ncbi.nlm.nih.gov/pubmed/11285219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.7.1547
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