Mapping the Prion Protein Using Recombinant Antibodies

The fundamental event in prion disease is thought to be the posttranslational conversion of the cellular prion protein (PrP(C)) into a pathogenic isoform (PrP(Sc)). The occurrence of PrP(C) on the cell surface and PrP(Sc) in amyloid plaques in situ or in aggregates following purification complicates...

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Main Authors: Williamson, R. Anthony, Peretz, David, Pinilla, Clemencia, Ball, Hadyn, Bastidas, Raiza B., Rozenshteyn, Roman, Houghten, Richard A., Prusiner, Stanley B., Burton, Dennis R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Viral Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC110372/
https://ncbi.nlm.nih.gov/pubmed/9765500
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