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Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein.

Prion diseases are disorders of protein conformation and do not provoke an immune response. Raising antibodies to the prion protein (PrP) has been difficult due to conservation of the PrP sequence and to inhibitory activity of alpha-PrP antibodies toward lymphocytes. To circumvent these problems, we...

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Detaylı Bibliyografya
Asıl Yazarlar: Williamson, R A, Peretz, D, Smorodinsky, N, Bastidas, R, Serban, H, Mehlhorn, I, DeArmond, S J, Prusiner, S B, Burton, D R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1996
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC38974/
https://ncbi.nlm.nih.gov/pubmed/8692983
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