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Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form
It is hypothesized that infectious prions are generated as the cellular form of the prion protein (PrP(C)) undergoes pronounced conformational change under the direction of an infectious PrP(Sc) template. Conversion to the infectious conformer is particularly associated with major structural rearran...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC145482/ https://ncbi.nlm.nih.gov/pubmed/11285219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.7.1547 |
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