Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form

It is hypothesized that infectious prions are generated as the cellular form of the prion protein (PrP(C)) undergoes pronounced conformational change under the direction of an infectious PrP(Sc) template. Conversion to the infectious conformer is particularly associated with major structural rearran...

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Main Authors: Leclerc, Estelle, Peretz, David, Ball, Haydn, Sakurai, Hiroshi, Legname, Giuseppe, Serban, Ana, Prusiner, Stanley B., Burton, Dennis R., Williamson, R.Anthony
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2001
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC145482/
https://ncbi.nlm.nih.gov/pubmed/11285219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.7.1547
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