IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

Uncontrolled mucosal immunity in the gastrointestinal tract of humans results in chronic inflammatory bowel disease (IBD), such as Crohn disease and ulcerative colitis. In early clinical trials as well as in animal models, IL-12 has been implicated as a major mediator of these diseases based on the...

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Autori principali: Yen, David, Cheung, Jeanne, Scheerens, Heleen, Poulet, Frédérique, McClanahan, Terrill, Mckenzie, Brent, Kleinschek, Melanie A., Owyang, Alex, Mattson, Jeanine, Blumenschein, Wendy, Murphy, Erin, Sathe, Manjiri, Cua, Daniel J., Kastelein, Robert A., Rennick, Donna
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1451201/
https://ncbi.nlm.nih.gov/pubmed/16670770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI21404
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