IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

Uncontrolled mucosal immunity in the gastrointestinal tract of humans results in chronic inflammatory bowel disease (IBD), such as Crohn disease and ulcerative colitis. In early clinical trials as well as in animal models, IL-12 has been implicated as a major mediator of these diseases based on the...

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Hauptverfasser: Yen, David, Cheung, Jeanne, Scheerens, Heleen, Poulet, Frédérique, McClanahan, Terrill, Mckenzie, Brent, Kleinschek, Melanie A., Owyang, Alex, Mattson, Jeanine, Blumenschein, Wendy, Murphy, Erin, Sathe, Manjiri, Cua, Daniel J., Kastelein, Robert A., Rennick, Donna
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1451201/
https://ncbi.nlm.nih.gov/pubmed/16670770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI21404
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