Anti–IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

IL-23 is a member of the IL-12 cytokine family that drives a highly pathogenic T cell population involved in the initiation of autoimmune diseases. We have shown that IL-23–dependent, pathogenic T cells produced IL-17A, IL-17F, IL-6, and TNF but not IFN-γ or IL-4. We now show that T-bet and STAT1 tr...

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Detalhes bibliográficos
Main Authors: Chen, Yi, Langrish, Claire L., Mckenzie, Brent, Joyce-Shaikh, Barbara, Stumhofer, Jason S., McClanahan, Terrill, Blumenschein, Wendy, Churakovsa, Tatyana, Low, Justin, Presta, Leonard, Hunter, Christopher A., Kastelein, Robert A., Cua, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450386/
https://ncbi.nlm.nih.gov/pubmed/16670771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25308
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