Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism

Cardiac myocytes contain two constitutive NO synthase (NOS) isoforms with distinct spatial locations, which allows for isoform-specific regulation. One regulatory mechanism for NOS is substrate (l-arginine) bioavailability. We tested the hypothesis that arginase (Arg), which metabolizes l-arginine,...

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Detalhes bibliográficos
Principais autores: Steppan, Jochen, Ryoo, Sungwoo, Schuleri, Karl H., Gregg, Chris, Hasan, Rani K., White, A. Ron, Bugaj, Lukasz J., Khan, Mehnaz, Santhanam, Lakshmi, Nyhan, Daniel, Shoukas, Artin A., Hare, Joshua M., Berkowitz, Dan E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450243/
https://ncbi.nlm.nih.gov/pubmed/16537391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506589103
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