Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats

There is increasing evidence that upregulation of arginase contributes to impaired endothelial function in aging. In this study, we demonstrate that arginase upregulation leads to endothelial nitric oxide synthase (eNOS) uncoupling and that in vivo chronic inhibition of arginase restores nitroso-red...

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Detalhes bibliográficos
Main Authors: Kim, Jae Hyung, Bugaj, Lukasz J., Oh, Young Jun, Bivalacqua, Trinity J., Ryoo, Sungwoo, Soucy, Kevin G., Santhanam, Lakshmi, Webb, Alanah, Camara, Andre, Sikka, Gautam, Nyhan, Daniel, Shoukas, Artin A., Ilies, Monica, Christianson, David W., Champion, Hunter C., Berkowitz, Dan E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763842/
https://ncbi.nlm.nih.gov/pubmed/19661445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.91393.2008
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