Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats

There is increasing evidence that upregulation of arginase contributes to impaired endothelial function in aging. In this study, we demonstrate that arginase upregulation leads to endothelial nitric oxide synthase (eNOS) uncoupling and that in vivo chronic inhibition of arginase restores nitroso-red...

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Bibliografiset tiedot
Päätekijät: Kim, Jae Hyung, Bugaj, Lukasz J., Oh, Young Jun, Bivalacqua, Trinity J., Ryoo, Sungwoo, Soucy, Kevin G., Santhanam, Lakshmi, Webb, Alanah, Camara, Andre, Sikka, Gautam, Nyhan, Daniel, Shoukas, Artin A., Ilies, Monica, Christianson, David W., Champion, Hunter C., Berkowitz, Dan E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2009
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763842/
https://ncbi.nlm.nih.gov/pubmed/19661445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.91393.2008
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