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The 3D profile method for identifying fibril-forming segments of proteins
Based on the crystal structure of the cross-β spine formed by the peptide NNQQNY, we have developed a computational approach for identifying those segments of amyloidogenic proteins that themselves can form amyloid-like fibrils. The approach builds on experiments showing that hexapeptides are suffic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1449648/ https://ncbi.nlm.nih.gov/pubmed/16537487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511295103 |
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