The 3D profile method for identifying fibril-forming segments of proteins

Based on the crystal structure of the cross-β spine formed by the peptide NNQQNY, we have developed a computational approach for identifying those segments of amyloidogenic proteins that themselves can form amyloid-like fibrils. The approach builds on experiments showing that hexapeptides are suffic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Thompson, Michael J., Sievers, Stuart A., Karanicolas, John, Ivanova, Magdalena I., Baker, David, Eisenberg, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2006
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449648/
https://ncbi.nlm.nih.gov/pubmed/16537487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511295103
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg