The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo

We studied inhibition of histone deacetylases (HDACs), which results in the unraveling of chromatin, facilitating increased gene expression. ITF2357, an orally active, synthetic inhibitor of HDACs, was evaluated as an anti-inflammatory agent. In lipopolysaccharide (LPS)-stimulated cultured human per...

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Detalhes bibliográficos
Main Authors: Leoni, Flavio, Fossati, Gianluca, Lewis, Eli C, Lee, Jae-Kwon, Porro, Giulia, Pagani, Paolo, Modena, Daniela, Moras, Maria Lusia, Pozzi, Pietro, Reznikov, Leonid L, Siegmund, Britta, Fantuzzi, Giamila, Dinarello, Charles A, Mascagni, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2005
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449516/
https://ncbi.nlm.nih.gov/pubmed/16557334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/2006-00005.Dinarello
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