Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)

ITF2357 (givinostat) is a histone deacetylase inhibitor with antiinflammatory properties at low nanomolar concentrations. We report here a phase I safety and pharmacokinetics trial in healthy males administered 50, 100, 200, 400 or 600 mg orally. After 50 mg, mean maximal plasma concentrations reach...

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Detalhes bibliográficos
Main Authors: Furlan, Antonio, Monzani, Valmen, Reznikov, Leonid L, Leoni, Flavio, Fossati, Gianluca, Modena, Daniela, Mascagni, Paolo, Dinarello, Charles A
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105139/
https://ncbi.nlm.nih.gov/pubmed/21365126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00020
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