The Histone Deacetylase Inhibitor ITF2357 Decreases Surface CXCR4 and CCR5 Expression on CD4+ T-Cells and Monocytes and is Superior to Valproic Acid for Latent HIV-1 Expression in Vitro

OBJECTIVES: Chromatin-associated repression is one mechanism that maintains HIV-1 latency. Inhibition of histone deacetylases (HDAC) reverses this repression resulting in viral expression from quiescently infected cells. Clinical studies with the HDAC inhibitor valproic acid (VPA) failed to substant...

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Hauptverfasser: Matalon, Shay, Palmer, Brent E., Nold, Marcel F., Furlan, Antonio, Kassu, Afework, Fossati, Gianluca, Mascagni, Paolo, Dinarello, Charles A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534976/
https://ncbi.nlm.nih.gov/pubmed/20300007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3181d3dca3
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