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Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury

Despite efforts aimed at developing novel therapeutics for traumatic brain injury (TBI), no specific pharmacological agent is currently clinically available. Here, we show that the pan-histone deacetylase (HDAC) inhibitor ITF2357, a compound shown to be safe and effective in humans, improves functio...

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Main Authors: Shein, Na'ama A., Grigoriadis, Nikolaos, Alexandrovich, Alexander G., Simeonidou, Constantina, Lourbopoulos, Athanasios, Polyzoidou, Eleni, Trembovler, Victoria, Mascagni, Paolo, Dinarello, Charles A., Shohami, Esther
格式: Artigo
語言:Inglês
出版: The Federation of American Societies for Experimental Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812044/
https://ncbi.nlm.nih.gov/pubmed/19723705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-134700
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