The Oral Histone Deacetylase Inhibitor ITF2357 Reduces Cytokines and Protects Islet β Cells In Vivo and In Vitro

In type 1 diabetes, inflammatory and immunocompetent cells enter the islet and produce proinflammatory cytokines such as interleukin-1β (IL-1β), IL-12, tumor necrosis factor-α (TNFα) and interferon-γ (IFNγ); each contribute to β-cell destruction, mediated in part by nitric oxide. Inhibitors of histo...

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Bibliographic Details
Main Authors:	Lewis, Eli C, Blaabjerg, Lykke, Størling, Joachim, Ronn, Sif G, Mascagni, Paolo, Dinarello, Charles A, Mandrup-Poulsen, Thomas
Format:	Artigo
Language:	Inglês
Published:	ScholarOne 2011
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3105153/ https://ncbi.nlm.nih.gov/pubmed/21193899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2010.00152
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The Oral Histone Deacetylase Inhibitor ITF2357 Reduces Cytokines and Protects Islet β Cells In Vivo and In Vitro

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