Preclinical Studies in the mdx Mouse Model of Duchenne Muscular Dystrophy with the Histone Deacetylase Inhibitor Givinostat

Previous work has established the existence of dystrophin–nitric oxide (NO) signaling to histone deacetylases (HDACs) that is deregulated in dystrophic muscles. As such, pharmacological interventions that target HDACs (that is, HDAC inhibitors) are of potential therapeutic interest for the treatment...

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Main Authors: Consalvi, Silvia, Mozzetta, Chiara, Bettica, Paolo, Germani, Massimiliano, Fiorentini, Francesco, Del Bene, Francesca, Rocchetti, Maurizio, Leoni, Flavio, Monzani, Valmen, Mascagni, Paolo, Puri, Pier Lorenzo, Saccone, Valentina
Format: Artigo
Sprog:Inglês
Udgivet: ScholarOne 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667212/
https://ncbi.nlm.nih.gov/pubmed/23552722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2013.00011
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