The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

Suberoylanilide hydroxamic acid (SAHA) is a hydroxamic acid-containing hybrid polar molecule; SAHA specifically binds to and inhibits the activity of histone deacetylase. Although SAHA, like other inhibitors of histone deacetylase, exhibits antitumor effects by increasing expression of genes regulat...

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Detalhes bibliográficos
Main Authors: Leoni, Flavio, Zaliani, Andrea, Bertolini, Giorgio, Porro, Giulia, Pagani, Paolo, Pozzi, Pietro, Donà, Giancarlo, Fossati, Gianluca, Sozzani, Silvano, Azam, Tania, Bufler, Philip, Fantuzzi, Giamila, Goncharov, Igor, Kim, Soo-Hyun, Pomerantz, Benjamin J., Reznikov, Leonid L., Siegmund, Britta, Dinarello, Charles A., Mascagni, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122461/
https://ncbi.nlm.nih.gov/pubmed/11867742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052702999
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