Specific Inhibition of Histone Deacetylase 8 Reduces Gene Expression and Production of Proinflammatory Cytokines in Vitro and in Vivo

ITF2357 (generic givinostat) is an orally active, hydroxamic-containing histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties, which has been used to treat children with systemic juvenile idiopathic arthritis. ITF2357 inhibits both Class I and II HDACs and reduces caspase-1 ac...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Suzhao, Fossati, Gianluca, Marchetti, Carlo, Modena, Daniela, Pozzi, Pietro, Reznikov, Leonid L., Moras, Maria Luisa, Azam, Tania, Abbate, Antonio, Mascagni, Paolo, Dinarello, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303687/
https://ncbi.nlm.nih.gov/pubmed/25451941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.618454
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