The phosphoinositide-3-kinase inhibitor PX-866 overcomes resistance to the EGFR inhibitor gefitinib in A-549 human non small cell lung cancer xenografts.

Epidermal growth factor receptor (EGFR) inhibitors such as gefitinib show antitumor activity in a subset of non small cell lung (nscl) cancer patients having mutated EGFR. Recent work shows that phosphatidylinositol-3-kinase (PtdIns-3-kinase) is coupled to the EGFR only in nscl cancer cell lines exp...

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Detalhes bibliográficos
Main Authors: Ihle, Nathan T., Paine-Murrieta, Gillian, Berggren, Margareta I., Baker, Amanda, Tate, Wendy R., Wipf, Peter, Abraham, Robert T., Kirkpatrick, D. Lynn, Powis, Garth
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1432090/
https://ncbi.nlm.nih.gov/pubmed/16170026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-05-0149
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