The PPARγ agonist pioglitazone prevents the hyperglycemia caused by phosphoinositide-3-kinase pathway inhibition by PX-866 without affecting antitumor activity

The PI-3-kinase/Akt signaling cascade is an important component of the insulin signaling in normal tissues leading to glucose uptake and homeostasis, and for cell survival signaling in cancer cells. Hyperglycemia is an on-target side effect of many inhibitors of PI-3-kinase/Akt signaling including t...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Ihle, Nathan T., Lemos, Robert, Schwartz, David, Oh, Junghwan, Halter, Robert J., Wipf, Peter, Kirkpatrick, Lynn, Powis, Garth
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633941/
https://ncbi.nlm.nih.gov/pubmed/19139117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0714
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk