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The PPARγ agonist pioglitazone prevents the hyperglycemia caused by phosphoinositide-3-kinase pathway inhibition by PX-866 without affecting antitumor activity
The PI-3-kinase/Akt signaling cascade is an important component of the insulin signaling in normal tissues leading to glucose uptake and homeostasis, and for cell survival signaling in cancer cells. Hyperglycemia is an on-target side effect of many inhibitors of PI-3-kinase/Akt signaling including t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633941/ https://ncbi.nlm.nih.gov/pubmed/19139117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0714 |
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