Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 while oncogenic Ras is a dominant predictor for resistance

The novel phosphatidylinositol-3-kinase (PI-3-kinase) inhibitor PX-866 was tested against 13 experimental human tumor xenografts derived from cell lines of various tissue origins. Mutant PI-3-kinase (PIK3CA) and loss of PTEN activity were sufficient but not necessary as predictors of sensitivity to...

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Detalhes bibliográficos
Main Authors: Ihle, NathanT., Lemos, Robert, Wipf, Peter, Yacoub, Adly, Mitchell, Clint, Siwak, Doris, Mills, Gordon B., Dent, Paul, Kirkpatrick, D Lynn., Powis, Garth
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613546/
https://ncbi.nlm.nih.gov/pubmed/19117997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6656
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