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Molecular pharmacology and antitumor activity of palmarumycin based inhibitors of thioredoxin reductase.

The cytosolic thioredoxin (Trx) redox system comprising Trx-1 and the NADPH dependent thioredoxin reductase -1 reductase (TrxR-1) is an important regulator of cell growth and survival. Trx-1 is overexpressed in many human tumors where it is associated with increased cell proliferation, decreased apo...

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Bibliografiske detaljer
Main Authors: Powis, Garth, Wipf, Peter, Lynch, Stephen M., Birmingham, Anne, Kirkpatrick, D. Lynn
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462925/
https://ncbi.nlm.nih.gov/pubmed/16546977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-05-0487
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