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Molecular pharmacology and antitumor activity of palmarumycin based inhibitors of thioredoxin reductase.
The cytosolic thioredoxin (Trx) redox system comprising Trx-1 and the NADPH dependent thioredoxin reductase -1 reductase (TrxR-1) is an important regulator of cell growth and survival. Trx-1 is overexpressed in many human tumors where it is associated with increased cell proliferation, decreased apo...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1462925/ https://ncbi.nlm.nih.gov/pubmed/16546977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-05-0487 |
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