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The skin and hair as surrogate tissues for measuring the target effect of inhibitors of phosphoinositide-3-kinase signaling.
BACKGROUND: The purpose of the study was to evaluate the use of phospho-Akt in mouse and human skin as a surrogate target for tumor phospho-Akt to measure the effect of antitumor inhibitors of phosphatidylinositol-3-kinase (PI-3-K) /Akt (protein kinase B) signaling. METHOD: The expression of phospho...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1486800/ https://ncbi.nlm.nih.gov/pubmed/16485116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-006-0190-0 |
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