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The skin and hair as surrogate tissues for measuring the target effect of inhibitors of phosphoinositide-3-kinase signaling.

BACKGROUND: The purpose of the study was to evaluate the use of phospho-Akt in mouse and human skin as a surrogate target for tumor phospho-Akt to measure the effect of antitumor inhibitors of phosphatidylinositol-3-kinase (PI-3-K) /Akt (protein kinase B) signaling. METHOD: The expression of phospho...

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Main Authors: Williams, Ryan, Baker, Amanda F., Ihle, Nathan T., Winkler, Ashley R., Kirkpatrick, Lynn, Powis, Garth
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1486800/
https://ncbi.nlm.nih.gov/pubmed/16485116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-006-0190-0
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