Quadruple Mutations in Dihydrofolate Reductase of Plasmodium falciparum Isolates from Car Nicobar Island, India

Quadruple mutations in the Plasmodium falciparum dihydrofolate reductase (PFDHFR) enzyme give rise to the highest level of pyrimethamine resistance leading to treatment failures. We describe here the presence of these quadruple mutations in a majority of P. falciparum isolates from Car Nicobar (Anda...

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Hlavní autoři: Ahmed, Anwar, Das, Manoj K., Dev, Vas, Saifi, Muheet A., Wajihullah, Sharma, Yagya D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426982/
https://ncbi.nlm.nih.gov/pubmed/16569880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1546-1549.2006
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