Characteristics of Genetic Hitchhiking around Dihydrofolate Reductase Gene Associated with Pyrimethamine Resistance in Plasmodium falciparum Isolates from India

Sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum has been widespread across continents, causing the major hurdle of controlling malaria. Resistance is encoded mainly by point mutations in P. falciparum dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) target ge...

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Hlavní autoři: Lumb, Vanshika, Das, Manoj K., Singh, Neeru, Dev, Vas, Wajihullah, Sharma, Yagya D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786369/
https://ncbi.nlm.nih.gov/pubmed/19786603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00045-09
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