Specific functional interactions of nucleotides at key (−)3 and (+)4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex

Eukaryotic initiation factor (eIF) 1 maintains the fidelity of initiation codon selection and enables mammalian 43S preinitiation complexes to discriminate against AUG codons with a context that deviates from the optimum sequence GCC(A/G)CC AUGG, in which the purines at (−)3 and (+)4 positions are m...

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Detalhes bibliográficos
Main Authors: Pisarev, Andrey V., Kolupaeva, Victoria G., Pisareva, Vera P., Merrick, William C., Hellen, Christopher U.T., Pestova, Tatyana V.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1410799/
https://ncbi.nlm.nih.gov/pubmed/16510876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1397906
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