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Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
Sterol 27-hydroxylase (CYP27A1) is required for bile acid synthesis by both the classical and alternate pathways. Cyp27a1(−/−) mice exhibit a dramatic increase in the activity of cytochrome P450 3A (CYP3A), which catalyzes side-chain hydroxylations of bile acid intermediates, thereby facilitating th...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140933/ https://ncbi.nlm.nih.gov/pubmed/12509506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237082100 |
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