Human Immunodeficiency Virus Type 1 Nucleocapsid Zn(2+) Fingers Are Required for Efficient Reverse Transcription, Initial Integration Processes, and Protection of Newly Synthesized Viral DNA

Human immunodeficiency virus type 1 (HIV-1) containing mutations in the nucleocapsid (NC) Zn(2+) finger domains have greatly reduced infectivity, even though genome packaging is largely unaffected in certain cases. To examine replication defects, viral DNA (vDNA) was isolated from cells infected wit...

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Main Authors: Buckman, James S., Bosche, William J., Gorelick, Robert J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2003
Ábhair:
Replication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC140799/
https://ncbi.nlm.nih.gov/pubmed/12502862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.1469-1480.2003
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