Subtle Alterations of the Native Zinc Finger Structures Have Dramatic Effects on the Nucleic Acid Chaperone Activity of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein

The nucleocapsid protein (NC) of human immunodeficiency virus type 1 has two zinc fingers, each containing the invariant CCHC zinc-binding motif; however, the surrounding amino acid context is not identical in the two fingers. Recently, we demonstrated that zinc coordination is required when NC unfo...

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Detalhes bibliográficos
Main Authors: Guo, Jianhui, Wu, Tiyun, Kane, Bradley F., Johnson, Donald G., Henderson, Louis E., Gorelick, Robert J., Levin, Judith G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155087/
https://ncbi.nlm.nih.gov/pubmed/11932404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.9.4370-4378.2002
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