Subtle Alterations of the Native Zinc Finger Structures Have Dramatic Effects on the Nucleic Acid Chaperone Activity of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein

The nucleocapsid protein (NC) of human immunodeficiency virus type 1 has two zinc fingers, each containing the invariant CCHC zinc-binding motif; however, the surrounding amino acid context is not identical in the two fingers. Recently, we demonstrated that zinc coordination is required when NC unfo...

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Foilsithe in:	J Virol
Príomhchruthaitheoirí:	Guo, Jianhui, Wu, Tiyun, Kane, Bradley F., Johnson, Donald G., Henderson, Louis E., Gorelick, Robert J., Levin, Judith G.
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	American Society for Microbiology (ASM) 2002
Ábhair:	Replication
Rochtain ar líne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155087/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11932404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.9.4370-4378.2002
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