Human Immunodeficiency Virus Type 1 Nucleocapsid Zn(2+) Fingers Are Required for Efficient Reverse Transcription, Initial Integration Processes, and Protection of Newly Synthesized Viral DNA

Human immunodeficiency virus type 1 (HIV-1) containing mutations in the nucleocapsid (NC) Zn(2+) finger domains have greatly reduced infectivity, even though genome packaging is largely unaffected in certain cases. To examine replication defects, viral DNA (vDNA) was isolated from cells infected wit...

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Εκδόθηκε σε:	J Virol
Κύριοι συγγραφείς:	Buckman, James S., Bosche, William J., Gorelick, Robert J.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2003
Θέματα:	Replication
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140799/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502862/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.2.1469-1480.2003
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