Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System

Targeted disruption of the retinoblastoma gene in mice leads to embryonic lethality in midgestation accompanied by defective erythropoiesis. Rb(−/−) embryos also exhibit inappropriate cell cycle activity and apoptosis in the central nervous system (CNS), peripheral nervous system (PNS), and ocular l...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	MacPherson, D., Sage, J., Crowley, D., Trumpp, A., Bronson, R. T., Jacks, T.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140709/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12529408/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.3.1044-1053.2003
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