Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System

Targeted disruption of the retinoblastoma gene in mice leads to embryonic lethality in midgestation accompanied by defective erythropoiesis. Rb(−/−) embryos also exhibit inappropriate cell cycle activity and apoptosis in the central nervous system (CNS), peripheral nervous system (PNS), and ocular l...

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Main Authors: MacPherson, D., Sage, J., Crowley, D., Trumpp, A., Bronson, R. T., Jacks, T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC140709/
https://ncbi.nlm.nih.gov/pubmed/12529408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.1044-1053.2003
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