Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System

Targeted disruption of the retinoblastoma gene in mice leads to embryonic lethality in midgestation accompanied by defective erythropoiesis. Rb(−/−) embryos also exhibit inappropriate cell cycle activity and apoptosis in the central nervous system (CNS), peripheral nervous system (PNS), and ocular l...

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Bibliographische Detailangaben
Hauptverfasser: MacPherson, D., Sage, J., Crowley, D., Trumpp, A., Bronson, R. T., Jacks, T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC140709/
https://ncbi.nlm.nih.gov/pubmed/12529408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.1044-1053.2003
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