The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1

TASK-1 encodes an acid- and anaesthetic-sensitive background K(+) current, which sets the resting membrane potential of both cerebellar granule neurons and somatic motoneurons. We demonstrate that TASK-1, unlike the other two pore (2P) domain K(+) channels, is directly blocked by submicromolar conce...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	EMBO J
Autori principali:	Maingret, François, Patel, Amanda J., Lazdunski, Michel, Honoré, Eric
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140203/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226154/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.1.47
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!