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An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1

The 2P domain K(+) channel TREK-1 is widely expres sed in the nervous system. It is opened by a variety of physical and chemical stimuli including membrane stretch, intracellular acidosis and polyunsaturated fatty acids. This activation can be reversed by PKA-mediated phosphorylation. The C-terminal...

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Autors principals: Honoré, Eric, Maingret, François, Lazdunski, Michel, Patel, Amanda Jane
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC126047/
https://ncbi.nlm.nih.gov/pubmed/12065410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf288
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