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An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1
The 2P domain K(+) channel TREK-1 is widely expres sed in the nervous system. It is opened by a variety of physical and chemical stimuli including membrane stretch, intracellular acidosis and polyunsaturated fatty acids. This activation can be reversed by PKA-mediated phosphorylation. The C-terminal...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126047/ https://ncbi.nlm.nih.gov/pubmed/12065410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf288 |
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