An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1
The 2P domain K(+) channel TREK-1 is widely expres sed in the nervous system. It is opened by a variety of physical and chemical stimuli including membrane stretch, intracellular acidosis and polyunsaturated fatty acids. This activation can be reversed by PKA-mediated phosphorylation. The C-terminal...
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| Publicat a: | EMBO J |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126047/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12065410/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf288 |
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