An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1

The 2P domain K(+) channel TREK-1 is widely expres sed in the nervous system. It is opened by a variety of physical and chemical stimuli including membrane stretch, intracellular acidosis and polyunsaturated fatty acids. This activation can be reversed by PKA-mediated phosphorylation. The C-terminal...

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Pubblicato in:	EMBO J
Autori principali:	Honoré, Eric, Maingret, François, Lazdunski, Michel, Patel, Amanda Jane
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126047/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12065410/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf288
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