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The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1
TASK-1 encodes an acid- and anaesthetic-sensitive background K(+) current, which sets the resting membrane potential of both cerebellar granule neurons and somatic motoneurons. We demonstrate that TASK-1, unlike the other two pore (2P) domain K(+) channels, is directly blocked by submicromolar conce...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140203/ https://ncbi.nlm.nih.gov/pubmed/11226154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.1.47 |
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