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The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1

TASK-1 encodes an acid- and anaesthetic-sensitive background K(+) current, which sets the resting membrane potential of both cerebellar granule neurons and somatic motoneurons. We demonstrate that TASK-1, unlike the other two pore (2P) domain K(+) channels, is directly blocked by submicromolar conce...

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Udgivet i:EMBO J
Principais autores: Maingret, François, Patel, Amanda J., Lazdunski, Michel, Honoré, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140203/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226154/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.1.47
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