The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1
TASK-1 encodes an acid- and anaesthetic-sensitive background K(+) current, which sets the resting membrane potential of both cerebellar granule neurons and somatic motoneurons. We demonstrate that TASK-1, unlike the other two pore (2P) domain K(+) channels, is directly blocked by submicromolar conce...
Kaydedildi:
| Yayımlandı: | EMBO J |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2001
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140203/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226154/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.1.47 |
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