Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation

Ribonucleotide reductase catalyzes a crucial step in de novo DNA synthesis and is allosterically controlled by relative levels of dNTPs to maintain a balanced pool of deoxynucleoside triphosphates in the cell. In eukaryotes, the enzyme comprises a heterooligomer of α(2) and β(2) subunits. The α subu...

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Detaylı Bibliyografya
Asıl Yazarlar: Xu, Hai, Faber, Catherine, Uchiki, Tomoaki, Fairman, James W., Racca, Joseph, Dealwis, Chris
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1389704/
https://ncbi.nlm.nih.gov/pubmed/16537479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600443103
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